Scalable peptide synthesis platforms combining Liquid-Phase (LPPS), Solid-Phase (SPPS), and hybrid fragment coupling technologies. We deliver high-purity linear, cyclic, and modified peptides with stringent epimerization control from development to commercial scale.
Advanced Peptide Development & Manufacturing
Scalable Synthesis Technologies for Short, Long, and Complex Peptides
At Anax Laboratories, our peptide platform offers end-to-end development and cGMP-aligned manufacturing for therapeutic and diagnostic peptides. By leveraging complementary synthesis platforms—Liquid-Phase Peptide Synthesis (LPPS), Solid-Phase Peptide Synthesis (SPPS), and Hybrid Segment Condensation—we tailor the synthetic route to sequence length, solubility profile, and target volume to achieve superior diastereomeric purity and cost efficiency.
Core Peptide Synthesis Platforms
- Liquid-Phase Peptide Synthesis (LPPS):
Optimized for commercial-scale manufacturing of short-to-medium peptides (2 to 10 amino acids). LPPS eliminates expensive solid supports, curtails organic solvent consumption, and allows straightforward real-time in-process analytical monitoring at every elongation step.
- Solid-Phase Peptide Synthesis (SPPS):
Automated, high-efficiency synthesis utilizing Fmoc and Boc chemistries for longer sequences, complex epitopes, and constrained macrocycles.
- Hybrid Segment Condensation:
Synthesis of protected peptide fragments via SPPS followed by convergent liquid-phase coupling, maximizing overall chemical yield while reducing deletion impurities in challenging, aggregation-prone sequences.
Specialized Chemical Modifications & Complex Peptidomimetics
Our process chemistry team handles a broad spectrum of structural modifications:
- Cyclization Chemistries: Head-to-tail, head-to-side-chain, and single or multiple intramolecular disulfide bridge formation.
- N- and C-Terminal Functionalization: Acetylation, amidation, fatty acid acylation (e.g., lipidated GLP-1/GIP analogues), biotinylation, and fluorescent labeling.
- Unnatural & D-Amino Acids: Seamless integration of non-proteinogenic amino acids, beta-amino acids, and N-methylated residues to enhance metabolic stability and in vivo half-life.
- Conjugation-Ready Peptides: Functionalized peptide sequences with orthogonal protection schemes designed for downstream attachment to polymers (PEGylation), targeted payloads, or GalNAc ligands.
Purification, Isolation & Quality Control
- Preparative Chromatography: Multi-kilogram purification capability utilizing preparative reverse-phase HPLC (RP-HPLC) columns and ion-exchange chromatography to isolate target peaks with purity 98.0%.
- Controlled Isolation & Lyophilization: Large-capacity pilot and production freeze-dryers (lyophilizers) providing precise control over residual solvent limits, moisture content, and counter-ion exchange (acetate, trifluoroacetate, or chloride salts).
- Comprehensive Release Analytics: Complete impurity profiling, sequence confirmation, and release testing via LC-MS/MS, HRMS, chiral HPLC (D/L enantiomeric purity), and amino acid analysis (AAA).